These changes are called BP amplifications. 1 In a healthy compliant vasculature systolic blood pressure (SBP) and pulse pressure (PP) increase, whereas diastolic blood pressure (DBP) decreases slightly from the central to the peripheral arterial tree. The arterial blood pressure (BP) waveform is transformed as it travels from the ascending aorta to the peripheral arteries. Moreover, given that the ejection time also depends on blood pressure, heart rate and pulse wave velocity, peripherally measured ejection times might need to be adjusted to account for changes in these variables. The time difference between centrally and peripherally measured ejection times likely reflects intrinsic vascular characteristics. Moreover, the ejection time prolongation was accentuated at lower blood pressures, lower heart rate and lower pulse wave velocity. The peripheral ejection time was significantly longer than the simultaneously measured central ejection time (174.5☒5.2 ms vs. Continuous wave Doppler waveform images through the aortic valve and the simultaneously obtained radial artery pressure waveforms were analyzed to determine central and peripheral ejection times, respectively. Moreover, we examined/accessed the modulating influence of hemodynamics on ejection time measurements. Our goal was to determine if the left ventricular ejection time measured peripherally in the arterial tree accurately reflected the ejection time measured through the aortic valve. However, the arterial waveform undergoes constant transformation as the pulse wave propagates along the arterial tree. The left ventricular ejection time is routinely measured from a peripheral arterial waveform.
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